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HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response

9 Jun 2021

Abstract excerpt

Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1-E2-E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5...

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PMID: 34207696
DOI: 10.3390/v13061102

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