Article

<i>APC</i> Mutation marks an aggressive subtype of <i>BRAF</i> mutant colorectal cancers

2020-02-17

Abstract excerpt

<h4>Background & Aims</h4> WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here we evaluate the mutational landscape of WNT signaling regulators in BRAF mutant cancers. <h4>Methods</h4> We performed exome-sequencing on 24 BRAF mutant colorectal cancers and analysed these...

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Literature Corpus work: f1f7e905-5a16-5f1b-aa97-a6ef477dc90d
DOI: 10.1101/2020.02.16.942904

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