Article

<i>KRAS</i> allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer <i>in vivo</i>

2023-08-30

Abstract excerpt

Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-type allele in KRAS mutant cancers. However, there is still much debate over the function of wild-type KRAS in tumour initiation, progression and therapeutic response. We hav...

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Literature Corpus work: f139c328-03e1-5a28-8fb9-69838471b1b6
DOI: 10.1101/2023.08.29.555396

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