Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.

doi:10.1053/j.gastro.2025.10.011

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Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.

Gastroenterology - 1 Mar 2026

Sommer Anna K, Te Paske Iris B A W, Jansen Erik A M, Gschwind Axel, Demidov German, Steinke-Lange Verena, Spier Isabel, Steyaert Wouter, Yaldiz Burcu, Steehouwer Marloes, Hommerding Oliver, Dietrich Dimo, Peters Sophia, Garcia-Pelaez José, Laner Andreas, Oliveira Carla, Capellá Gabriel, Nagtegaal Iris D, Bläker Hendrik, Ellwanger Kornelia, Hoischen Alexander, Gilissen Christian, van der Post Rachel S, Kristiansen Glen, Hoogerbrugge Nicoline, Ossowski Stephan, Valle Laura, Holinski-Feder Elke, Ligtenberg Marjolijn J L, Aretz Stefan, de Voer Richarda M

Abstract excerpt

BACKGROUND & AIMS: Individuals with colorectal polyposis are suspected to be genetically predisposed to tumor development. However, in around half of adenomatous and the vast majority of serrated polyposis patients, no explanatory pathogenic germline variant is found in routine diagnostics. Here, we aimed to improve the characterization of the early steps of polyp formation and provide clues on the tumorigenic...

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PMID: 41524686
DOI: 10.1053/j.gastro.2025.10.011

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