Article
Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers.
Scientific reports - 6 Dec 2021
Grant Adam, Xicola Rosa M, Nguyen Vivian, Lim James, Thorne Curtis, Salhia Bodour, Llor Xavier, Ellis Nathan, Padi Megha
Abstract excerpt
The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development. Recent studies have found that early-onset CRC exhibits an increased proportion of tumors lacking an APC mutation. We set out to identify mechanisms underlying APC...
Topics
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Colorectal Neoplasms
- DNA Copy Number Variations
- DNA Methylation
- Disease Progression
- Genes, APC
- Humans
- Microsatellite Instability
- Microsatellite Repeats
- Mutation
- Neoplastic Processes
- Phenotype