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APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers

6 May 2020

Abstract excerpt

Background: WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here, we evaluate the mutational landscape of WNT signaling regulators in BRAF mutant cancers. Methods: we performed exome-sequencing on 24 BRAF mutant colorectal cancers and analyzed these data in combination with...

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PMID: 32384699
DOI: 10.3390/cancers12051171

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