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Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains <i>Kras</i> mutant intestinal neoplasia

2023-12-23

Abstract excerpt

<h4>Background</h4> Serrated neoplasia accounts for ∼25% of colorectal cancer. These cancers arise from serrated precursor lesions. Hyperplastic polyps initiated by either BRAF or KRAS mutation activating MAPK signalling are common, but premalignant sessile serrated lesions with KRAS mutation are rare. Here, we model Kras and Braf mutant neoplasia in vivo to compare histological, gene expression and DNA met...

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Literature Corpus work
158b7ed0-987d-5dbd-bc3c-d3583717499e
DOI
10.1101/2023.12.21.572936
Open publication

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Attenuation of the CpG Island Methylator Phenotype and lack of WNT signaling activation restrains <i>Kras</i> mutant intestinal neoplasiaDOI 10.1101/2023.12.21.572936
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