Article

Prevalence and consequences of<i>APC</i>mosaicism in patients with colorectal adenomas

2025-02-20

Abstract excerpt

<h4>Background and aims</h4> A substantial proportion of patients with adenomatous polyposis have no germline pathogenic variant in APC . The aim of this study was to determine the prevalence of APC mosaicism in these patients with unexplained polyposis and to draft guidelines for APC mosaicism testing and surveillance. <h4>Methods</h4> APC mosaicism was analyzed by targeted Next-Generation sequencing in 542 patie...

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Literature Corpus work: 460ba9f1-b618-5e46-8bc4-de9e7cb3662e
DOI: 10.1101/2025.02.18.25322465

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