Article
Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer.
Neoplasia (New York, N.Y.) - 1 Feb 2020
Kane Alexandra M, Fennell Lochlan J, Liu Cheng, Borowsky Jennifer, McKeone Diane M, Bond Catherine E, Kazakoff Stephen, Patch Ann-Marie, Koufariotis Lambros T, Pearson John, Waddell Nicola, Leggett Barbara A, Whitehall Vicki L J
Abstract excerpt
The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAFV600E and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite instability, which have an excellent clinical outcome. However, a proportion of BRAF mutant CRC retain microsatellite stability and have a dismal prognosis. The molecular...
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