Article

Molecular Drivers of Tumor Progression in Microsatellite Stable <i>APC</i> Mutation-Negative Colorectal Cancers

2021-09-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The tumor suppressor gene adenomatous polyposis coli ( APC ) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development. Recent studies have found that early-onset CRC exhibits an increased proportion of tumors lacking an APC mutation. We set out to id...

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Literature Corpus work: 77ea6828-2018-5d58-9459-a54202a7a8d1
DOI: 10.1101/2021.09.14.460319

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