Back to search

Article

The earliest stages of neoplastic transformation in Familial Adenomatous Polyposis

2025-05-22

Abstract excerpt

<title>Abstract</title> <p>The succession of somatic genetic events associated with the conversion of a normal colorectal epithelial cell into a colorectal carcinoma constitutes a paradigmatic model of cancer development. Familial Adenomatous Polyposis (FAP) is caused by constitutional inactivating mutations in <italic>APC</italic>, the central gatekeeper gene of colorectal cancer, and is associated with a substa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
81655046-ce67-580d-a4b0-3d76e2eec9d0
DOI
10.21203/rs.3.rs-6581155/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The earliest stages of neoplastic transformation in Familial Adenomatous PolyposisDOI 10.21203/rs.3.rs-6581155/v1
The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity
The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity
Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancersSemantic proximity
Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.Semantic proximity
Polyclonal origins of human premalignant colorectal lesionsSemantic proximity
Adenoma development in familial adenomatous polyposis and MUTYH ‐associated polyposis: somatic landscape and driver genesSemantic proximity
The somatic mutation landscape of premalignant colorectal adenoma.Semantic proximity
Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.Semantic proximity
An enhanced genetic model of colorectal cancer progression historySemantic proximity
New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity
Somatic targeted mutation profiling of colorectal cancer precursor lesionsSemantic proximity
Somatic targeted mutation profiling of colorectal cancer precursor lesions.Semantic proximity
Select a neighboring publication to make it the new centre.