Article

A dual sensor regulates P-glycoprotein’s structural plasticity

2026-03-15

Abstract excerpt

P-glycoprotein is an efflux pump with an exceptionally broad substrate profile which drives its profound clinical impact. Despite its biological importance, it remains obscure how P-glycoprotein achieves its polyspecificity and how substrate binding and the lipid environment stimulate its activity. Structural data highlight the importance of transmembrane helices 4 and 10, which surround the binding pocket, and id...

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Literature Corpus work: f1dc0d48-a005-5ae9-829a-790236381c6c
DOI: 10.64898/2026.03.13.711505

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