Structural insight into binding site access and ligand recognition by human ABCB1

Abstract excerpt

ABCB1 is a broad-spectrum efflux pump central to cellular drug handling and multidrug resistance in humans. However, its mechanisms of poly-specific substrate recognition and transport remain poorly resolved. Here we present cryo-EM structures of lipid embedded human ABCB1 in its apo, substrate-bound, inhibitor-bound, and nucleotide-trapped states at 3.4-3.9 Å resolution without using stabilizing antibodies or mut...

Topics

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• ATP Binding Cassette Transporter, Subfamily B
• Biological Transport
• Cholesterol and Lipid Metabolism
• Cryoelectron Microscopy
• Drug Transport and Resistance Mechanisms
• Epitopes
• HIV/AIDS drug development and treatment
• Immunoglobulin Fab Fragments

Identifiers and source

Literature Corpus work

04d8508e-f34a-591d-8dc3-1e09d17a7034

DOI

10.1101/2024.08.12.607598