Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the Role of P-gp in Multidrug Resistance: Insights from Recent Structural Studies

28 Apr 2025

Abstract excerpt

P-glycoprotein (P-gp/ABCB1), a key ATP-binding cassette (ABC) transporter, plays a central role in multidrug resistance (MDR), one of the leading causes of chemotherapy failure in cancer treatment. P-gp actively pumps chemotherapeutic agents out of cancer cells, reducing intracellular drug concentration and compromising therapeutic efficacy. Recent advancements in structural biology, particularly cryogenic...

Source

Identifiers

PMID: 40362415
DOI: 10.3390/ijms26094179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the Role of P-gp in Multidrug Resistance: Insights from Recent Structural StudiesPMID 40362415Read ↗

Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug ResistanceSemantic proximity Read ↗

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal modelsSemantic proximity Read ↗

The Structure and Functions of P-GlycoproteinSemantic proximity Read ↗

Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4Semantic proximity Read ↗

Mutational analysis reveals the importance of residues of the access tunnel inhibitor site to human P-glycoprotein (ABCB1)-mediated transport.Semantic proximity Read ↗

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.Semantic proximity Read ↗

Structure of the human multidrug transporter ABCG2.Semantic proximity Read ↗

A dual sensor regulates P-glycoprotein’s structural plasticitySemantic proximity Read ↗

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.Semantic proximity Read ↗

Tracing the substrate translocation mechanism in P-glycoproteinSemantic proximity Read ↗

Mechanism of multidrug resistance to chemotherapy mediated by P‑glycoprotein (Review)Semantic proximity Read ↗

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.