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Mapping the Role of P-gp in Multidrug Resistance: Insights from Recent Structural Studies

28 Apr 2025

Abstract excerpt

P-glycoprotein (P-gp/ABCB1), a key ATP-binding cassette (ABC) transporter, plays a central role in multidrug resistance (MDR), one of the leading causes of chemotherapy failure in cancer treatment. P-gp actively pumps chemotherapeutic agents out of cancer cells, reducing intracellular drug concentration and compromising therapeutic efficacy. Recent advancements in structural biology, particularly cryogenic...

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PMID: 40362415
DOI: 10.3390/ijms26094179

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