Article

Ligandability at the membrane interface of GPx4 revealed through a reverse micelle fragment screening platform

2024-05-12

Abstract excerpt

While they account for a large portion of drug targets, membrane proteins (MPs) present a unique challenge for drug discovery. Peripheral membrane proteins (PMPs), a class of proteins that bind reversibly to membranes, are also difficult targets, particularly those that function only while bound to membranes. The protein-membrane interface in PMPs is often where functional interactions and catalysis occur, making...

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Literature Corpus work: a5fc941f-1e50-55e5-95d7-72ac7e97d940
DOI: 10.1101/2024.05.09.593437

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