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Article

Energetic and structural control of polyspecificity in a multidrug transporter.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2025

Miller Silas T, Henzler-Wildman Katherine A, Raman Srivatsan

Abstract excerpt

Multidrug efflux pumps are dynamic molecular machines that drive antibiotic resistance by harnessing ion gradients to export chemically diverse substrates. Despite their clinical importance, the molecular principles underlying multidrug promiscuity and energy efficiency remain poorly understood. Using multiparametric deep mutational scanning across eight substrates and two energy conditions, we deconvolute the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41433063
DOI: 10.1073/pnas.2511892122
PMCID: PMC12772156

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