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Article

Tracing the substrate translocation mechanism in P-glycoprotein.

eLife - 23 Jan 2024

Gewering Theresa, Waghray Deepali, Parey Kristian, Jung Hendrik, Tran Nghi N B, Zapata Joel, Zhao Pengyi, Chen Hao, Januliene Dovile, Hummer Gerhard, Urbatsch Ina, Moeller Arne, Zhang Qinghai

Abstract excerpt

P-glycoprotein (Pgp) is a prototypical ATP-binding cassette (ABC) transporter of great biological and clinical significance.Pgp confers cancer multidrug resistance and mediates the bioavailability and pharmacokinetics of many drugs (Juliano and Ling, 1976; Ueda et al., 1986; Sharom, 2011). Decades of structural and biochemical studies have provided insights into how Pgp binds diverse compounds (Loo and Clarke,...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38259172
DOI: 10.7554/eLife.90174
PMCID: PMC10945689

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