Article

Structural basis of substrate recognition and translocation by human ABCA4

2021-02-27

Abstract excerpt

Human ATP-binding cassette (ABC) subfamily A (ABCA) transporters mediate the transport of various lipid compounds across the membrane. Mutations in human ABCA transporters have been described to cause severe hereditary disorders associated with impaired lipid transport. However, little is known about the mechanistic details of substrate recognition and translocation by ABCA transporters. Here, we present three cry...

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Literature Corpus work: 57471f4e-e4d7-5fec-aae1-15e25f3086c9
DOI: 10.1101/2021.02.27.433154

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