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Article

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.

Science (New York, N.Y.) - 23 Feb 2018

Kim Youngjin, Chen Jue

Abstract excerpt

The multidrug transporter permeability (P)-glycoprotein is an adenosine triphosphate (ATP)-binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein extrudes toxic molecules and drugs from cells through ATP-powered conformational changes. Despite decades of effort, only the structures of the inward-facing conformation of P-glycoprotein are available. Here we present the...

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Identifiers

PMID: 29371429
DOI: 10.1126/science.aar7389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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