Tracing the substrate translocation mechanism in P-glycoprotein

Abstract excerpt

P-glycoprotein (Pgp) is a prototypical ABC transporter of great biological and clinical significance that confers cancer multidrug resistance and mediates the bioavailability and pharmacokinetics of many drugs 1–3 . Decades of structural and biochemical studies have provided insights into how Pgp binds diverse compounds 4–9 , but how they are translocated through the membrane has remained elusive. Here, we coval...

Topics

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• Adenosine Triphosphate
• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• ATP-Binding Cassette Transporters
• Crystallography, X-Ray
• Mutation
• Protein Domains
• Translocation, Genetic

Identifiers and source

Literature Corpus work

20273ab5-9a43-580b-b8d2-7b9dc157d65e

DOI

10.1101/2022.04.28.489897