Article

Energetic and structural control of polyspecificity in a multidrug transporter

2025-04-10

Abstract excerpt

Multidrug efflux pumps are dynamic molecular machines that drive antibiotic resistance by harnessing ion gradients to export chemically diverse substrates. Despite their clinical importance, the molecular principles underlying multidrug promiscuity and energy efficiency remain poorly understood. Using multiparametric deep mutational scanning across eight substrates and two energy conditions, we deconvolute the con...

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Literature Corpus work: 7b414901-f2ef-57db-9e5e-b576ecc60a18
DOI: 10.1101/2025.04.09.647630

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