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Article

Structures of ABCB4 provide insight into phosphatidylcholine translocation.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021

Nosol Kamil, Bang-Sørensen Rose, Irobalieva Rossitza N, Erramilli Satchal K, Stieger Bruno, Kossiakoff Anthony A, Locher Kaspar P

Abstract excerpt

ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi. The mechanism of specific lipid recruitment from the canalicular membrane, which is essential to mitigate the cytotoxicity of bile salts, is poorly understood. We present cryogenic electron microscopy structures of human ABCB4 in three distinct functional conformations. An apo-inward structure reveals how phospholipid can...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34385322
DOI: 10.1073/pnas.2106702118
PMCID: PMC8379956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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