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Structural insights into binding-site access and ligand recognition by human ABCB1

13 Jan 2025

Abstract excerpt

ABCB1 is a broad-spectrum efflux pump central to cellular drug handling and multidrug resistance in humans. However, how it is able to recognize and transport a wide range of diverse substrates remains poorly understood. Here we present cryo-EM structures of lipid-embedded human ABCB1 in conformationally distinct apo-, substrate-bound, inhibitor-bound, and nucleotide-trapped states at 3.4-3.9 Å resolution, in the...

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PMID: 39806099
DOI: 10.1038/s44318-025-00361-z

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