APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.

doi:10.1038/s41467-026-76565-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.

Nature communications - 19 Aug 2026

Cuní-López Carla, Root Jessica T, Hao Ying, Blomberg Niek, Koppes-den Hertog Sascha J, Sacks Dylan, Trujillo Amber E, Ghirlando Rodolfo, Kowal Isabelle, Epstein Jacob, Yang Linda G, Cookson Mark R, Marsan Elise, van der Kant Rik, Giera Martin, Qi Yue Andy, Narayan Priyanka S

Abstract excerpt

Lipid droplets are dynamic cellular organelles that store neutral lipids and coordinate metabolic and stress-response pathways. In the brain, lipid droplets in glial cells, including astrocytes, have been implicated in Alzheimer's disease, but how genetic risk factors influence their composition and turnover remains poorly understood. APOE is the strongest genetic modulator of late-onset Alzheimer's disease and...

Read the complete abstract on PubMed

Topics

Humans
Astrocytes
Lipid Droplets
Proteome
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apolipoprotein E4

Alzheimer Disease

Autophagy

Apolipoprotein E3

Apolipoproteins E

Apolipoprotein E2

Oleic Acid

Induced Pluripotent Stem Cells

Lipid Metabolism

Source

Open in PubMed Open full text

Identifiers

PMID: 42749735
DOI: 10.1038/s41467-026-76565-6
PMCID: PMC13582944

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.PMID 42749735Read ↗

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read ↗

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.Semantic proximity Read ↗

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4Semantic proximity Read ↗

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.Semantic proximity Read ↗

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytesSemantic proximity Read ↗

An arrayed CRISPR/Cas9 screen identifies mTORC1 as a regulator of lipid droplet accumulation in APOE E3 and APOE KO iPSC-derived microgliaSemantic proximity Read ↗

Genome-wide CRISPR screen reveals Wnt signaling defects regulate lipid accumulation in APOE4 oligodendrocytesSemantic proximity Read ↗

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in NeuronsSemantic proximity Read ↗

<i>APOE4</i> alters the lipid droplet proteome and modulates droplet dynamicsSemantic proximity Read ↗

APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microgliaSemantic proximity Read ↗

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet sizeSemantic proximity Read ↗

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human MicrogliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.