Article

<i>APOE4</i> alters the lipid droplet proteome and modulates droplet dynamics

2024-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Excess lipid droplet (LD) accumulation is associated with several pathological states, including Alzheimer’s disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics contribute to pathophysiology of these disorders remains unclear. Apolipoprotein E (ApoE) is a droplet associated protein with a common risk variant (E4) that confers the largest increase in genetic ri...

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Literature Corpus work: d3cbe1e3-8737-5242-9b48-b83da54c4ed3
DOI: 10.1101/2024.12.16.628710

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