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<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics

2025-08-20

Abstract excerpt

The lipids and proteins that comprise lipid droplets regulate several cellular functions including lipid storage, stress responses, and inflammation. Glial lipid droplets have been implicated in the pathogenesis and progression of Alzheimer’s disease (AD), yet the mechanisms linking genetic risk to lipid droplet biology remain unclear. Here we examined how APOE , the strongest genetic modulator of late-onset AD,...

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Literature Corpus work
bdc81976-34f9-5437-9ff9-f6a2a83567a4
DOI
10.1101/2025.08.19.669163
Open publication

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<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsDOI 10.1101/2025.08.19.669163
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