Article

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia

2026-05-13

Abstract excerpt

<h4>SUMMARY</h4> While Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for late-onset Alzheimer’s disease, its mechanistic role in the brain-resident macrophage, microglia, remains elusive. Microglia are important in the clearance of pathology in disease, heavily relying on lysosome functionality; therefore, we sought to understand the impact of APOE4 on microglial function. APOE44 microglia h...

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Literature Corpus work: d6480e82-9de5-53f2-8a96-72cb8ce62953
DOI: 10.64898/2026.05.12.724612

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