Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism.

Cell reports - 5 Jan 2021

Qi Guoyuan, Mi Yashi, Shi Xiaojian, Gu Haiwei, Brinton Roberta Diaz, Yin Fei

Abstract excerpt

Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid metabolism is unclear. Here, we describe a detrimental role of ApoE4 in regulating fatty acid (FA) metabolism across neuron and astrocyte in tandem with their distinctive mitochondrial phenotypes. ApoE4 disrupts neuronal function by...

Topics

Join the communities discussing this publication.

Apolipoprotein E4
Astrocytes
Energy Metabolism
Fatty Acids
Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipid Metabolism

Source

Open in PubMed Open full text

Identifiers

PMID: 33406436
DOI: 10.1016/j.celrep.2020.108572
PMCID: PMC7837265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism.PMID 33406436Read ↗

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.Semantic proximity Read ↗

Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-βSemantic proximity Read ↗

APOE Genotype Impacts Polyunsaturated Neutral Lipid Storage and Ferroptosis Vulnerability in Astrocytes.Semantic proximity Read ↗

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read ↗

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet sizeSemantic proximity Read ↗

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in NeuronsSemantic proximity Read ↗

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microgliaSemantic proximity Read ↗

Apolipoprotein E in lipid metabolism and neurodegenerative disease.Semantic proximity Read ↗

<i>APOE4</i> drives widespread changes to the hepatic proteome and alters metabolic functionSemantic proximity Read ↗

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human MicrogliaSemantic proximity Read ↗

Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia.Semantic proximity Read ↗

Protective ApoE variants support neuronal function by extracting peroxidated lipidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.