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Article

APOE Genotype Impacts Polyunsaturated Neutral Lipid Storage and Ferroptosis Vulnerability in Astrocytes.

Neurochemical research - 26 Jun 2025

Richards Sarah E V, Yang Maddie, Deik Amy A, Ricq Emily L

Abstract excerpt

Astrocytes play a critical role in regulating the metabolism of cholesterol and other lipids in the brain. Increasing evidence suggests that dysfunctional lipid metabolism and lipid peroxide-mediated cell death, or ferroptosis, are involved in the pathophysiology of late-onset Alzheimer’s disease. The Alzheimer’s disease risk allele of APOE, APOE4, is expressed in astrocytes and is associated with increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40571761
DOI: 10.1007/s11064-025-04463-2

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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