Article

An AluYb8 retrotransposon characterises a risk haplotype of TMEM106B associated in neurodegeneration

2023-07-16

Abstract excerpt

Genome-wide association studies identified a role for TMEM106B in various neurodegenerative diseases. Based on long-read whole-genome sequencing data of 256 individuals, we identified an AluYb8 retrotransposon in the 3’ UTR of the risk haplotype of TMEM106B . When transcriptionally active, Alu-elements can propogate throughout the genome, and mediate (post-)transcriptional dysregulation of nearby genes. We found t...

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Literature Corpus work: f19699ef-5306-5238-aac8-8e1f1cd04702
DOI: 10.1101/2023.07.16.23292721

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