Article
A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.
American journal of human genetics - 2 Nov 2017
Gallagher Michael D, Posavi Marijan, Huang Peng, Unger Travis L, Berlyand Yosef, Gruenewald Analise L, Chesi Alessandra, Manduchi Elisabetta, Wells Andrew D, Grant Struan F A, Blobel Gerd A, Brown Christopher D, Chen-Plotkin Alice S
Abstract excerpt
Neurodegenerative diseases pose an extraordinary threat to the world's aging population, yet no disease-modifying therapies are available. Although genome-wide association studies (GWASs) have identified hundreds of risk loci for neurodegeneration, the mechanisms by which these loci influence disease risk are largely unknown. Here, we investigated the association between common genetic variants at the 7p21 locus...
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