Article

A dementia-associated risk variant near <i>TMEM106B</i> alters chromatin architecture and gene expression

2017-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases pose an extraordinary threat to the world’s aging population, yet no disease-modifying therapies are available. While genome-wide association studies (GWAS) have identified hundreds of novel risk loci for neurodegeneration, the mechanisms by which these loci influence disease risk are largely unknown. Indeed, of the many thousands of SNP-trait associations identified b...

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Literature Corpus work: 7d5c2f57-6a37-5435-9984-b244d546c895
DOI: 10.1101/154989

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