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Article

A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2024

Rodney Alana, Karanjeet Kul, Benzow Kellie, Koob Michael D

Abstract excerpt

INTRODUCTION: Sequence variants in TMEM106B have been associated with an increased risk of developing dementia. METHODS: As part of our efforts to generate a set of mouse lines in which we replaced the mouse Tmem106b gene with a human TMEM106B gene comprised of either a risk or protective haplotype, we conducted an in-depth sequence analysis of these alleles. We also analyzed transcribed TMEM106B sequences using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38924247
DOI: 10.1002/alz.14090
PMCID: PMC11247663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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