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Article

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.

Neurology - 3 Mar 2015

Yu Lei, De Jager Philip L, Yang Jingyun, Trojanowski John Q, Bennett David A, Schneider Julie A

Abstract excerpt

OBJECTIVE: To determine the independent association of the TMEM106B variants with transactive response DNA binding protein 43 (TDP-43) pathology in older persons without frontotemporal lobar degeneration (FTLD) and to explore functional pathways that link the risk variants to the pathology, including a GRN mRNA pathway. METHODS: Data came from 544 autopsied participants without FTLD in 2 community-based studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25653292
DOI: 10.1212/WNL.0000000000001313
PMCID: PMC4351662

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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