Article

A common Alu element insertion in the 3’UTR of <i>TMEM106B</i> is associated with an increased risk of dementia

2023-09-08

Abstract excerpt

Sequence variants in TMEM106B have been associated with an increased risk of developing several different types of dementia. As part of our efforts to generate a set of mouse lines in which we replaced the mouse Tmem106b gene with a human TMEM106B gene comprised of either a risk or protective haplotype, we conducted an in-depth sequence analysis of these alleles. We identified an AluYb8 insertion in the 3’ untr...

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Literature Corpus work: 05f5ccee-2934-5dc4-869b-e644a7987fdd
DOI: 10.1101/2023.09.07.555370

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