Article

A 3’UTR Insertion Is a Candidate Causal Variant at the<i>TMEM106B</i>Locus Associated with Increased Risk for FTLD-TDP

2023-07-08

Abstract excerpt

<h4>Background and Objectives</h4> Single nucleotide variants near TMEM106B associate with risk of frontotemporal lobar dementia with TDP-43 inclusions (FTLD-TDP) and Alzheimer’s disease (AD) in genome-wide association studies (GWAS), but the causal variant at this locus remains unclear. Here we asked whether a novel structural variant on TMEM106B is the causal variant. <h4>Methods</h4> An exploratory analysis ide...

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Literature Corpus work: 8d54b434-3d32-5a0e-a990-6638dd9ff542
DOI: 10.1101/2023.07.06.23292312

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