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Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and cognitively healthy longevity

2025-02-06

Abstract excerpt

Genetic variation at the TMEM106B locus has been associated with Alzheimers disease (AD) and related neurodegenerative phenotypes, yet its haplotypic architecture remains incompletely resolved. We refined the genetic landscape of TMEM106B by integrating AD-GWAS summary statistics (~978K individuals) with haplotype analyses in 5,873 Dutch genomes including AD-cases, age-matched controls, and cognitively healthy cen...

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Literature Corpus work
dafe19c1-bfd8-5a8e-bcde-51c556c0f186
DOI
10.1101/2025.02.02.25321330
Open publication

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Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and cognitively healthy longevityDOI 10.1101/2025.02.02.25321330
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