Article

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

2023-03-25

Abstract excerpt

TMEM106B is a risk modifier for a growing list of age-associated dementias including Alzheimer’s and frontotemporal dementia, yet its function remains elusive. Two key questions that emerge from past work are whether the conservative T185S coding variant found in the minor haplotype contributes to protection, and whether the presence of TMEM106B is helpful or harmful in the context of disease. Here we address both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbadd352-3689-5e62-b56f-5d16b965b15d
DOI: 10.1101/2023.03.23.533978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathyDOI 10.1101/2023.03.23.533978Read

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.Semantic proximity Read

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.Semantic proximity Read

A common Alu element insertion in the 3’UTR of <i>TMEM106B</i> is associated with an increased risk of dementiaSemantic proximity Read

Gene specific effects on brain volume and cognition of<i>TMEM106B</i>in frontotemporal lobar degenerationSemantic proximity Read

Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.Semantic proximity Read

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human DiseaseSemantic proximity Read

What we know about TMEM106B in neurodegeneration.Semantic proximity Read

A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.Semantic proximity Read

<i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brainSemantic proximity Read

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human DiseaseSemantic proximity Read

TMEM106B haplotypes have distinct gene expression patterns in aged brainSemantic proximity Read

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.Semantic proximity Read