Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What we know about TMEM106B in neurodegeneration.

Acta neuropathologica - 1 Nov 2016

Nicholson Alexandra M, Rademakers Rosa

Abstract excerpt

Frontotemporal lobar degeneration is a neurodegenerative disorder affecting over 50,000 people in the United States alone. The most common pathological subtype of FTLD is the presence of ubiquitinated TAR DNA binding protein 43 (TDP-43) accumulations in frontal and temporal brain regions at autopsy. While some cases of FTLD-TDP can be attributed to the inheritance of disease-causing mutations, the majority of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 7
Share to DNA-Binding Proteins
Share to Frontotemporal Dementia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27543298
DOI: 10.1007/s00401-016-1610-9
PMCID: PMC5074873

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What we know about TMEM106B in neurodegeneration.PMID 27543298Read ↗

TMEM106B a novel risk factor for frontotemporal lobar degeneration.Semantic proximity Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Semantic proximity Read ↗

TMEM106B expression is reduced in Alzheimer’s disease brainsSemantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.Semantic proximity Read ↗

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.Semantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.Semantic proximity Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.