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Article

TMEM106B a novel risk factor for frontotemporal lobar degeneration.

Journal of molecular neuroscience : MN - 1 Nov 2011

van der Zee Julie, Van Broeckhoven Christine

Abstract excerpt

Recently, the first genome-wide association (GWA) study in frontotemporal lobar degeneration (FTLD) identified common genetic variability at the TMEM106B gene on chromosome 7p21.3 as a potential important risk-modifying factor for FTLD with pathologic inclusions of TAR DNA-binding protein (FTLD-TDP), the most common pathological subtype in FTLD. To gather additional evidence for the implication of TMEM106B in...

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Identifiers

PMID: 21614538
DOI: 10.1007/s12031-011-9555-x
PMCID: PMC3207134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

TMEM106B a novel risk factor for frontotemporal lobar degeneration.PMID 21614538Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.Semantic proximity Read ↗

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.Semantic proximity Read ↗

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Semantic proximity Read ↗

TMEM106B is a susceptibility locus for Ftld.Semantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions.Semantic proximity Read ↗

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.Semantic proximity Read ↗

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Semantic proximity Read ↗

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.Semantic proximity Read ↗

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