Article

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin <i>in cis</i>

2018-03-07

Abstract excerpt

Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure and expression of host chromatin by the human retrovirus HTLV-1. We show that HTLV-1 disrupts host chromatin structure by forming loops between the provirus and t...

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Literature Corpus work: f10328bf-a4de-52bf-a795-0d0613779eca
DOI: 10.1101/277335

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