Article

Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis

2024-05-28

Abstract excerpt

During HTLV-1 infection, the virus integrates into the host cell genome as a provirus with a single CCCTC binding protein (CTCF) binding site (vCTCF-BS), which acts as an insulator between transcriptionally active and inactive regions. Previous studies have shown that the vCTCF-BS is important for maintenance of chromatin structure, regulation of viral expression, and DNA and histone methylation. Here, we show tha...

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Literature Corpus work: ba3ddf55-e189-5b14-aedf-9a717e89df40
DOI: 10.1101/2024.05.28.596170

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