Back to search

Article

Histone H1 Promotes Silencing of Unintegrated HIV-1 DNA

2025-11-07

Abstract excerpt

In eukaryotic cells, genomic DNA is packaged into chromatin with nucleosomes formed by core histones H2A, H2B, H3, and H4, and further stabilized by the linker histone H1. During the early stages of retroviral infection, such as with murine leukemia virus (MLV) and human immunodeficiency virus type 1 (HIV-1), host core and H1 histones are rapidly deposited onto unintegrated viral DNAs upon nuclear entry. These uni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7ced4dde-3e06-5537-a351-2091b9f30525
DOI
10.1101/2025.11.07.687224
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Histone H1 Promotes Silencing of Unintegrated HIV-1 DNADOI 10.1101/2025.11.07.687224
Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silencedSemantic proximity
How to control an infectious bead string: nucleosome‐based regulation and targeting of herpesvirus chromatinSemantic proximity
YTHDF1 and YTHDC1 m <sup>6</sup> A reader proteins regulate HTLV-1 <i>tax</i> and <i>hbz</i> activitySemantic proximity
The Epstein–Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteinsSemantic proximity
Genome-wide analysis of histone modifications in latently HIV-1 infected T cellsSemantic proximity
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity
Epigenetic crosstalk in chronic infection with HIV-1Semantic proximity
Epigenetic Mechanisms of HIV-1 PersistenceSemantic proximity
HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modificationSemantic proximity
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity
Epigenetic regulation of HIV latencySemantic proximity
Intragenic silencer regulates human retrovirus latency by recruiting RUNX1Semantic proximity
Select a neighboring publication to make it the new centre.