Human immunodeficiency virus-1 induces host genomic R-loop and preferentially integrates its genome near the R-loop regions

Abstract excerpt

Although HIV-1 integration sites favor active transcription units in the human genome, high-resolution analysis of individual HIV-1 integration sites has shown that the virus can integrate into a variety of host genomic locations, including non-genic regions. The invisible infection by HIV-1 integrating into non-genic regions, challenging the traditional understanding of HIV-1 integration site selection, is more p...

Topics

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• CCCTC-Binding Factor
• Clone Cells
• CRISPR-Cas Systems
• Gene Editing
• HIV Research and Treatment
• Human T-lymphotropic virus 1
• Plant Virus Research Studies
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

f34e98e5-49ab-5354-9b94-59e163e12afb

DOI

10.1101/2024.03.06.583715