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Article

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis.

eLife - 26 Jun 2018

Melamed Anat, Yaguchi Hiroko, Miura Michi, Witkover Aviva, Fitzgerald Tomas W, Birney Ewan, Bangham Charles Rm

Abstract excerpt

Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure and expression of host chromatin by the human retrovirus HTLV-1. We show that HTLV-1 disrupts host chromatin structure by forming loops between the provirus and...

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Identifiers

PMID: 29941091
DOI: 10.7554/eLife.36245
PMCID: PMC6019074

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CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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