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Article

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.

PloS one - 1 Jan 2009

Felice Barbara, Cattoglio Claudia, Cittaro Davide, Testa Anna, Miccio Annarita, Ferrari Giuliana, Luzi Lucilla, Recchia Alessandra, Mavilio Fulvio

Abstract excerpt

Gamma-retroviruses and lentiviruses integrate non-randomly in mammalian genomes, with specific preferences for active chromatin, promoters and regulatory regions. Gene transfer vectors derived from gamma-retroviruses target at high frequency genes involved in the control of growth, development and differentiation of the target cell, and may induce insertional tumors or pre-neoplastic clonal expansions in patients...

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Identifiers

PMID: 19238208
DOI: 10.1371/journal.pone.0004571
PMCID: PMC2642719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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