Article
Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia.
Cell reports - 25 Apr 2023
Smits Willem K, Vermeulen Carlo, Hagelaar Rico, Kimura Shunsuke, Vroegindeweij Eric M, Buijs-Gladdines Jessica G C A M, van de Geer Ellen, Verstegen Marjon J A M, Splinter Erik, van Reijmersdal Simon V, Buijs Arjan, Galjart Niels, van Eyndhoven Winfried, van Min Max, Kuiper Roland, Kemmeren Patrick, Mullighan Charles G, de Laat Wouter, Meijerink Jules P P
Abstract excerpt
Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression. In patients with T cell acute lymphoblastic leukemia (T-ALL), we find that acquired monoallelic CTCF-inactivating events drive subtle and local genomic effects in nearly half of t(5; 14) (q35; q32.2)...
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