Article

Time-course of host cell transcription during the HTLV-1 transcriptional burst

2022-02-24

Abstract excerpt

The human T-cell leukemia virus type 1 (HTLV-1) transactivator protein Tax has pleiotropic functions in the host cell affecting cell-cycle regulation, DNA damage response pathways and apoptosis. These actions of Tax have been implicated in the persistence and pathogenesis of HTLV-1-infected cells. It is now known that tax expression occurs in transcriptional bursts of the proviral plus-strand, but the effects of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e50b279-3250-5060-9cea-5073adab6029
DOI: 10.1101/2022.02.24.481745

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Time-course of host cell transcription during the HTLV-1 transcriptional burstDOI 10.1101/2022.02.24.481745Read

Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1Semantic proximity Read

The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycleSemantic proximity Read

Retrovirus-induced leukemia – hijack of T-cell activation mechanisms revealed by single-cell analysisSemantic proximity Read

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read

Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells.Semantic proximity Read

YTHDF1 and YTHDC1 m <sup>6</sup> A reader proteins regulate HTLV-1 <i>tax</i> and <i>hbz</i> activitySemantic proximity Read

40 years of the human T-cell leukemia virus: past, present, and futureSemantic proximity Read

Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cellsSemantic proximity Read

Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype.Semantic proximity Read

Intra-pol proviral open region of HTLV-1 controls the transcription from both long terminal repeatsSemantic proximity Read

HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival.Semantic proximity Read

Quantification of HTLV-1 expression at the single-cell level in naturally-infected T-lymphocytesSemantic proximity Read