Article
Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF.
PLoS pathogens - 1 May 2021
Cheng Xiaogang, Joseph Ancy, Castro Victor, Chen-Liaw Alice, Skidmore Zachary, Ueno Takaharu, Fujisawa Jun-Ichi, Rauch Daniel A, Challen Grant A, Martinez Michael P, Green Patrick, Griffith Malachi, Payton Jacqueline E, Edwards John R, Ratner Lee
Abstract excerpt
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive T-cell malignancy and a variety of inflammatory conditions. The integrated provirus includes a single binding site for the epigenomic insulator, CCCTC-binding protein (CTCF), but its function remains unclear. In the current study, a mutant virus was examined that eliminates the CTCF-binding site. The mutation did not disrupt the...
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