Article

Selective clonal persistence of human retroviruses in vivo: radial chromatin organization, integration site and host transcription

2021-11-10

Abstract excerpt

The human retroviruses HTLV-1 and HIV-1 persist in vivo, despite the host immune response and antiretroviral therapy, as a reservoir of latently infected T-cell clones. It is poorly understood what determines which clones survive in the reservoir and which are lost. We compared >160,000 HTLV-1 integration sites from T-cells isolated ex vivo from naturally-infected subjects with >230,000 integration sites from in v...

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Literature Corpus work: 9164f7c2-4435-5548-92c0-33057ac47e49
DOI: 10.1101/2021.11.10.467892

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